May Strophanthin be a valuable cardiac drug ?

Research Article


Abstract views: 231 / PDF downloads: 127

Authors

  • Manfred Doepp

DOI:

https://doi.org/10.58372/2835-6276.1069

Keywords:

Strophantin, Ouabaine, Heart failure therapy, Glycosides, Digitalis

Abstract

There are cardiac glycosides obtained from various plants. One is the group of digitalis drugs and the other is Strophanthin (= ouabaine). They all have a positive inotropic effect, i.e. they strengthen the heart muscle, lower the heart rate and have an anti-arrhythmic effect. All glycosides are potentially toxic in overdoses, but digitalis is more so than Strophanthin. We have never experienced a toxic effect with Strophanthin. In contrast, we have found that Strophantin in the form of gastric juice-resistant capsules containing 3 mg has excellent effects in heart failure. The usual cardiological agents can thus be replaced by Strophanthin in many cases.

References

Faktenblatt zu Strofantine-G , auf sigmaaldrich.com , Sigma Aldrich.

A. Benedicenti, OUABAINA , in Enciclopedia Italiana , Rome, Istituto dell'Enciclopedia Italiana, 1935.

Wie ich Livingstone-Reisen, Abenteuer und Entdeckungen in Zentralafrika fand von Henry M. Stanley, 1872; zitiert in Marcello Nicoletti, Pharmazeutische Botanik: Geschichte, Aktivitäten und Verwendung von Heilpflanzen , EdiSES, 2007, S. 279, ISBN 978-88-7959-377-9 , OCLC 849072004 .

F. Senatore, Pharmazeutische Biologie und Botanik , 2. ed, PICCIN, ISBN 978-88-299-2126-3 .

F. Capasso and Rita De Pasquale, Pharmakognosie: Botanik, Chemie und Pharmakologie von Heilpflanzen , Springer Verlag, 2011, pp. 233–241, DOI : 10.1007/978-88-470-1652-1_16 , ISBN 978-88-470-1651-4

Natrium-Kalium-ATPase – Proteopedia, Leben in 3D , in: proteopedia.org

Ouabain – Proteopedia, Leben in 3D , in: proteopedia.org

OUABAIN | CAMEO-Chemikalien | NOAA , in: cameochemicals.noaa.gov .

B. G. Katzung and T. W. Vanderah, Basic & Clinical Pharmacology , 15. ed, ISBN 978-1-260-45231-0 .

OUABAIN , www.cameochemicals.noaa.gov , CAMEO Chemicals | NOAA.

C. Dollery, Therapeutic Drugs , vol. 2, 2. ed., Churchill Livingstone, 1999.

Ouabaina , su humanitas.it

Goodman, L.S. and A. Gilman., The Pharmacological Basis of Therapeutics , 5. ed, New York, Macmillan Publishers, 1975, p. 673 .

Gosselin, R. E., R. P. Smith und H. C. Hodge, Clinical Toxicology of Commercial Products , 5. ed, 1984, p. 842.

A. Osol (ed.), Remington's Pharmaceutical Sciences , 16. ed, Easton, Pennsylvania, Mack Publishing Co., 1980, p. 798.

Furstenwerth H., International Journal of Clinical Practice , vol. 64, 2010.

American Medical Association, AMA Drug Evaluations , 5. ed, Chicago, 1983, p. 611.

Ouabain unterscheidet zwischen Nikotin- und Muskarinrezeptor-vermittelten Katecholaminsekreten in durchbluteten Nebennieren von Katzen. , www.ncbi.nlm.nih.gov

Beobachtungen zur Natur, Biosynthese, Sekretion und Bedeutung von endogenem Ouabain , in: pubmed.ncbi.nlm.nih.gov

https://de.wikipedia.org/wiki/Glycoside

Albrecht R., Christen S., Alt und herzinsuffizient – wie findet man die optimale Behandlung? Der informierte Arzt 08 (2023) p. 38 (Switzerland)

https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines/CVD-Prevention-Guidelines

https://strophantus.de/

Downloads

Published

2023-09-15

How to Cite

Manfred Doepp. (2023). May Strophanthin be a valuable cardiac drug ? : Research Article. American Journal of Medical and Clinical Research & Reviews, 2(9), 1–6. https://doi.org/10.58372/2835-6276.1069

Issue

Section

Articles