https://ajmcrr.com/index.php/pub <p><strong>American Journal of Medical and Clinical Research &amp; Reviews (ISSN 2835-6276) </strong>is an internationally reputed open access journal that aims to publish a Low, Education and Biological diversity Multisisciplinary Sciences journal wide range of topics within the field of general medicine, advanced medicine, and its related clinical practices.The journal seeks original research in all the major clinical and medical sciences in the form of research articles, review articles, case studies, commentaries, short communication, and the letters to the editor This peer reviewed journal publishes evidence based empirical research on a wide range of topics within the fields of general medicine that includes Cardiology, Nephrology, Gynecology, Dermatology, Dentistry, Ophthalmology, Orthopedices, Neurology and Immunology for publication. The journal lays equal emphasis on the advanced scientific research on pediatrics, Critical care medicine, Family Medicine, Epidemiology, and Geriatrics. Specialized fields within the Translational Medicine, Nursing, Epidemiology, and Healthcare are encouraged for publication.</p> <p>Research on the major clinical practices involved in the general and advanced medical practices including but not limited to oncology, HIV/Aids, Infectious diseases, Surgery, Internal medicine, Orthopedics, and Neurology finds a place in this scientific journal.</p> American Journal of Medical and Clinical Research & Reviews en-US American Journal of Medical and Clinical Research & Reviews 2835-6276 https://ajmcrr.com/index.php/pub/article/view/324 <p><em>Intermittent fasting (IF) has emerged as a promising non-pharmacological intervention to mitigate cardiovascular risk and systemic inflammation in patients with autoimmune diseases. This review explores the mechanistic links between IF and improved endothelial function, with a focus on oxidative stress reduction, immune modulation, and metabolic reprogramming. Evidence from in vitro, animal, and early-phase human studies indicates that IF enhances nitric oxide availability, reduces pro-inflammatory cytokines, and promotes vascular protection through ketone body production and autophagy. While benefits such as improved flow-mediated dilation and decreased markers of vascular inflammation have been observed, significant challenges remain regarding the variability of fasting protocols, individual response, and the scarcity of long-term randomized controlled trials. Tailored fasting strategies, supported by omics approaches and circadian alignment, may provide a valuable adjunct in managing cardiovascular complications in autoimmune populations. Further research is essential to clarify the safety, efficacy, and personalization of IF regimens in this context.</em></p> Adawi Mohammad Yousef Awni Adawi Ahlam Copyright (c) 2025 American Journal of Medical and Clinical Research & Reviews https://creativecommons.org/licenses/by/4.0 2025-06-24 2025-06-24 4 7 1 18 10.58372/2835-6276.1311