Analysis of the potential of the homeopathic eye drops Marine Cineraria 4CH to induce cell migration

Research Article

Abstract

The ocular surface comprises diverse components that collaborate to maintain homeostasis, and any change can be termed an ocular surface disorder. One frequently observed change is the development of corneal ulcers, a primary contributor to visual impairment. Cineraria maritima is a botanical species renowned for its therapeutic application in managing diagnosed cataracts and other eye-related ailments. This study evaluated the effect of the homeopathic eye drops containing Cineraria maritima using cell viability assessments, a scratch experiment, and the quantification of IL-8 levels. The in vitro tests revealed the absence of any cytotoxic effects associated with the eye drops, thus demonstrating their safety for use. Furthermore, these eye drops exhibited the capacity to enhance the percentage of scratch closure. The treated group had an average closed area percentage of 57%, while the control group exhibited only 41% area closure, indicating the potential efficacy of eye drops in managing ocular disorders. Finally, IL-8 levels were measured following the induction of an inflammatory response by LPS and subsequent treatment with the eye drops. The outcomes indicate a decrease in the levels of this cytokine in the treated group. Such findings assure the safety and effectiveness of Cineraria maritima 4CH homeopathic eye drops, suggesting a potential avenue for their application to treat corneal ulcers.