Moringa Oleifera and Mitochondria – A Short Literature Review: Review Article

Daigo Hirao

doi:10.58372/2835-6276.1237

Authors

Daigo Hirao

DOI:

https://doi.org/10.58372/2835-6276.1237

Keywords:

Moringa oleifera, Mitochondrial Dysfunction, phytochemical constituents, neuroprotection, oxidative stress

Abstract

Mitochondrial dysfunction is a critical factor in the pathology of numerous diseases, impacting cellular energy production and metabolic processes. This review explores the potential of Moringa oleifera (MO), a well-established medicinal plant, in mitigating mitochondrial dysfunction. Highlighting its phytochemical components such as flavonoids, isothiocyanates and glycosides, this paper discusses their roles in reducing oxidative stress, combating inflammation and improving cellular health. Evidence from recent studies supports MO's capacity to restore mitochondrial functions, alleviate muscle atrophy and counteract neurodegenerative diseases. While promising, gaps in clinical research necessitate advanced trials to validate these findings and develop MO-based therapeutic interventions.

References

San-Millan, I. (2023, March). The Key Role of Mitochondrial Function in Health and Disease. Article | PubMed

Chen, W., Zhao, H., & Li, Y. (2023, September 06). Mitochondrial dynamics in health and disease: mechanisms and potential targets. Article | PubMed

Chhikara, N., Kaur, A., Mann, S., Garg, M., Sofi, S., & Panghal, A. (2021, February). Bioactive compounds, associated health benefits and safety considerations of Moringa oleifera L.: An updated review. Article

Prabakaran, M., Kim, S., Sasireka, A., Chandrasekaran, M., & Chung, I. (2018, December). Polyphenol composition and antimicrobial activity of various solvent extracts from different plant parts of Moringa oleifera. Article

Adewumi, O., Felix-Minnaar, J., & Jideani, V. (2022, January). Functional properties and amino acid profile of Bambara groundnut and Moringa oleifera leaf protein complex. Article

Luqman, S. (2012). Ferric reducing antioxidant power and free radical scavenging activity of Moringa oleifera: Relevance in oxidative stress. PDF

Aju, B., Rajalakshmi, R., & Mini, S. (2019, December). Protective role of Moringa oleifera leaf extract on cardiac antioxidant status and lipid peroxidation in streptozotocin induced diabetic rats. Article | PubMed

Ndlovu, S., Ghazi, T., & Chuturgoon, A. (2022, September). The Potential of Moringa oleifera to Ameliorate HAART-Induced Pathophysiological Complications. Article | PubMed | PMC

Jun, L., Robinson, M., Geetha, T., Broderick, T., & Babu, J. (2023, February 3). Prevalence and Mechanisms of Skeletal Muscle Atrophy in Metabolic Conditions. PubMed | PMC

Johri, A., & Beal, M. (2012, September). Mitochondrial Dysfunction in Neurodegenerative Diseases.PMC

Alqahtani, T., Deore, S., Kide, A., Shende, B., Sharma, R., Chakole, R., . . . Ghosh, A. (2023, July). Mitochondrial dysfunction and oxidative stress in Alzheimer’s disease, and Parkinson’s disease, Huntington’s disease and Amyotrophic Lateral Sclerosis -An updated review. Article

Chen, P., Yao, L., Yuan, M., Wang, Z., Zhang, Q., Jiang, Y., & Li, L. (2024, May). Mitochondrial dysfunction: A promising therapeutic target for liver diseases. Article | PubMed | PMC

Kowalczyk, P., Sulejczak, D., Kleczkowska, P., Bukowska-Ośko, I., Kucia, M., Popiel, M., . . . Kaczyńska, K. (2021, December). Mitochondrial Oxidative Stress—A Causative Factor and Therapeutic Target in Many Diseases. Article | PubMed | PMC

Ojaimi, M., Salah, A., & El-Hattab, A. (2022, September 16). Mitochondrial Fission and Fusion: Molecular Mechanisms, Biological Functions, and Related Disorders. Article | PubMed

Li, A., Gao, M., Liu, B., Qin, Y., Chen, L., Liu, H., Wu, H., & Gong, G. (2022, May 09). Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease. Article | PubMed

Behl, T., Makkar, R., Anwer, M., Hassani, R., Khuwaja, G., Khalid, A., . . . Rachamalla, M. (2023, April 14). Mitochondrial Dysfunction: A Cellular and Molecular Hub in Pathology of Metabolic Diseases and Infection. Article | PubMed | PMC

Min, K., Kwon, O., Smuder, A., Wiggs, M., Sollanek, K., Christou, D., . . . Powers, S. (2015). Increased mitochondrial emission of reactive oxygen species and calpain activation are required for doxorubicin-induced cardiac and skeletal muscle myopathy. Article | PubMed

Hyatt, H., & Powers, S. (2021, April 11). Mitochondrial Dysfunction Is a Common Denominator Linking Skeletal Muscle Wasting Due to Disease, Aging, and Prolonged Inactivity. Article | PubMed | PMC

Mishra, G., Singh, P., Verma, R., Kumar, S., Srivastav, S., Jha, K., & Khosa, R. (2011). Traditional uses, phytochemistry and pharmacological properties of Moringa oleifera plant: An overview. Article

Saleem, A., Saleem, M., & Akhtar, M. (2020, January). Antioxidant, anti-inflammatory and antiarthritic potential of Moringa oleifera Lam: An ethnomedicinal plant of Moringaceae family. Article

Kumar, S., Murti, Y., Arora, S., Akram, W., Bhardwaj, H., Gupta, K., . . . Saha, S. (2024, September). Exploring the therapeutic potential of Moringa oleifera Lam. in Traditional Chinese Medicine: A comprehensive review. Article

Annesley, S., & Fisher, P. (2019, July). Mitochondria in health and disease. Article | PubMed

Sakellariou, G., Pearson, T., Lightfoot, A., Nye, G., Wells, N., Giakoumaki, I., . . . McArdle, A. (2016, September). Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy. Article | PubMed

Chen, X., Ji, Y., Zhu, X., Wang, K., Yang, X., Liu, B., . . . Sun, H. (2023, July 26). Mitochondrial dysfunction: roles in skeletal muscle atrophy. Article

Kubat, G., Bouhamida, E., Ulger, O., Türkel, I., Pedriali, G., Ramaccini, D., . . . Pinton, P. (2023, July). Mitochondrial Dysfunction and Skeletal Muscle Atrophy: Causes, Mechanisms, and Treatment Strategies. Article | PubMed

Xu, S., Zhang, X., Liu, C., Liu, Q., Chai, H., Luo, Y., & Li, S. (2021, August). Role of Mitochondria in Neurodegenerative Diseases: From an Epigenetic Perspective. Article | PubMed | PMC

Saleem, M., Sohail, M., & Akhtar, A. (2024, October 23). MELAS syndrome and risk of infection. Article

Liu, Y., McIntyre, R., Janssens, G., & Houtkooper, R. (2020, March). Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease. Article | PubMed

Barros, C., Coutinho, A., & Tengan, C. (2024, March 24). Arginine Supplementation in MELAS Syndrome: What Do We Know about the Mechanisms? Article | PubMed

Almudhry, M., Prasad, A., Rupar, C., Tay, K., Ratko, S., Jenkins, M., & Prasad, C. (2023, September). A milder form of molybdenum cofactor deficiency type A presenting as Leigh's syndrome-like phenotype highlighting the secondary mitochondrial dysfunction: a case report. Article | PubMed | PMC

Kirindage, K., Fernando, I., Jayasinghe, A., Han, E.-J., Dias, M., Kang, K.-P., . . . Ahn, G. (2022, January). Moringa oleifera Hot Water Extract Protects Vero Cells from Hydrogen Peroxide-Induced Oxidative Stress by Regulating Mitochondria-Mediated Apoptotic Pathway and Nrf2/HO-1 Signaling. Article | PubMed

Fard, M., Arulselvan, P., Karthivashan, G., Adam, S., & Fakurazi, S. (2015, October). Bioactive Extract from Moringa oleifera Inhibits the Pro-inflammatory Mediators in Lipopolysaccharide Stimulated Macrophages.PubMed | PMC

Duranti, G., Maldini, M., Crognale, D., Sabatini, S., Corana, F., Horner, K., & Ceci, R. (2021, February). Moringa oleifera leaf extract influences oxidative metabolism in C2C12 myotubes through SIRT1-PPARα pathway. Article | PubMed

Hashim, F., Vichitphan, S., Boonsiri, P., & Vichitphan, K. (2021, April 28). Neuroprotective Assessment of Moringa oleifera Leaves Extract against Oxidative-Stress-Induced Cytotoxicity in SHSY5Y Neuroblastoma Cells. Article | PubMed

Azlan, U., Annuar, N., Mediani, A., Aizat, W., Damanhuri, H., Tong, X., . . . Hamezah, H. (2023, January). An insight into the neuroprotective and anti-neuroinflammatory effects and mechanisms of Moringa oleifera. Article | PubMed | PMC

Singh, S., Keshri, P., Mishra, V., & Singh, S. (2024, January 4). Moringa oleifera Modulates MPTP-induced Mitochondrial Dysfunction in Parkinson’s Mouse Model: An in silico and in vivo Analysis. Article

Adelakun, A., Awosika, A., Adabanya, U., Omole, A., Olopoda, A., & Bello, E. (2024, January). Antimicrobial and Synergistic Effects of Syzygium cumini, Moringa oleifera, and Tinospora cordifolia Against Different Candida Infections. Article | PMC

Pareek, A., Pant, M., Gupta, M., Kashania, P., Ratan, Y., Jain, V., . . . Chuturgoon, A. (2023, January). Moringa oleifera: An Updated Comprehensive Review of Its Pharmacological Activities, Ethnomedicinal, Phytopharmaceutical Formulation, Clinical, Phytochemical, and Toxicological Aspects.Article | PubMed | PMC

Shahbaz, M., Naeem, H., Batool, M., Imran, M., Hussain, M., Mujtaba, A., . . . Jbawi, E. (2024, July 09). Antioxidant, anticancer, and anti-inflammatory potential of Moringa seed and Moringa seed oil: A comprehensive approach. Article | PubMed