Primary sclerosing cholangitis revealed during pregnancy: case report
Case Report
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https://doi.org/10.58372/2835-6276.1282Abstract
Primary sclerosing cholangitis (PSC) is a cholangiopathy characterized by chronic fibroinflammatory damage of the biliary tree and is frequently associated with inflammatory bowel disease (IBD). Its association with pregnancy is exceptional and presents unique diagnostic and therapeutic challenges. We report a case of PSC revealed during pregnancy. It’s about a 30-year-old woman, gravida 1, para 0, with no significant medical history, presented at 16 weeks of pregnancy with intense pruritus and persistent fatigue. Laboratory findings revealed cholestasis with elevated alkaline phosphatase, gamma-glutamyl transferase, and transaminases. An abdominal ultrasound ruled out cholelithiasis, while MRCP demonstrated multifocal bile duct strictures, suggestive of PSC with a chronic liver disease. The patient was managed with Ursodeoxycholic acid and close multidisciplinary monitoring. Delivery occurred at term without major complications, and postpartum follow-up was established to monitor disease progression.
This case highlights the importance of considering PSC in atypical gestational cholestasis and underscores the need for a multidisciplinary approach to optimize maternal-fetal management.
References
Paumgartner G, Beuers U. Ursodeoxycholic acid in cholestatic liver disease: Mechanisms of action and therapeutic use revisited. Hepatology. sept 2002;36(3):525‑31.
Zollner G, Trauner M. Mechanisms of Cholestasis. Clin Liver Dis. févr 2008;12(1):1‑26.
Williamson C, Nana M, Poon L, Kupcinskas L, Painter R, Taliani G, et al. EASL Clinical Practice Guidelines on the management of liver diseases in pregnancy. J Hepatol. sept 2023;79(3):768‑828.
Janczewska I, Olsson R, Hultcrantz R, Broome U. Pregnancy in patients with primary sclerosing cholangitis. Liver. oct 1996;16(5):326‑30.
Wellge BE, Sterneck M, Teufel A, Rust C, Franke A, Schreiber S, et al. Pregnancy in primary sclerosing cholangitis. Gut. 1 août 2011;60(8):1117‑21.
Ludvigsson JF, Bergquist A, Ajne G, Kane S, Ekbom A, Stephansson O. A Population-based Cohort Study of Pregnancy Outcomes Among Women With Primary Sclerosing Cholangitis. Clin Gastroenterol Hepatol. janv 2014;12(1):95-100.e1.
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