Microgravity Changes detected by Carotid Hemodynamic Monitoring in Astronauts : Brief Report

Hilla Ben Pazi; Itamar Machol; Samuel Zibman; Samuel Goldstein; Meron Ben Pazi; Michelle Hong Chan; Ori Shriki; Shady Jahshan; Marc Ribo; Sagi Har-Nof; Harel Baris

doi:10.58372/2835-6276.1277

Authors

Hilla Ben Pazi
Itamar Machol
Samuel Zibman
Samuel Goldstein
Meron Ben Pazi
Michelle Hong Chan
Ori Shriki
Shady Jahshan
Marc Ribo
Sagi Har-Nof
Harel Baris

DOI:

https://doi.org/10.58372/2835-6276.1277

Keywords:

Pulse Wave Velocity, Deep learning, Carotid Artery, Hemodynamics, microgravity, space mission, Spaceflight Associated Neuro-Ocular Syndrome

Abstract

A study assessed continuous hemodynamic monitoring's viability for space missions, emphasizing the need to monitor venous hemodynamics due to microgravity's impact. Machine learning analyzed pulse wave data from astronauts' carotid arteries and jugular veins before and after a 17-day mission, effectively classifying three hemodynamic waveform variants that change in prevalence following microgravity exposure compared to preflight baseline. Jugular vein changes were more pronounced than arterial (p=0.02 vs. p=0.06). Significant differences in the diastole waveform shape between the baseline prevalent waveform variant and that of the prevalent waveform following exposure were observed (p<0.00001). Further studies are needed to assess venous monitoring for astronaut health on space missions.

References

Pelligra S, Casstevens EA, Matthews MJ, Edemekong PF. Aerospace Health Maintenance Wellness. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2023.

Martin Paez Y, Mudie LI, Subramanian PS. Spaceflight Associated Neuro-Ocular Syndrome (SANS): A Systematic Review and Future Directions. Eye Brain 2020;12:105–17.

Wojcik P, Kini A, Al Othman B, Galdamez LA, Lee AG. Spaceflight associated neuro-ocular syndrome. Curr Opin Neurol 2020;33(1):62–7.

Drudi LM, Grenon SM. The Vascular Frontier: Exploring the diagnosis and management of vascular conditions in spaceflight. Vasc Med Lond Engl 2022;27(4):373–4.

Makowski D, Pham T, Lau ZJ, et al. NeuroKit2: A Python toolbox for neurophysiological signal processing. Behav Res Methods 2021;53(4):1689–96.

Lim PK, Ng S-C, Lovell NH, et al. Adaptive template matching of photoplethysmogram pulses to detect motion artefact. Physiol Meas 2018;39(10):105005.

Rao A, Eskandar-Afshari F, Weiner Y, et al. Clinical Study of Continuous Non-Invasive Blood Pressure Monitoring in Neonates. Sensors 2023;23(7).

Auñón-Chancellor Serena M., Pattarini James M., Moll Stephan, Sargsyan Ashot. Venous Thrombosis during Spaceflight. N Engl J Med 2020;382(1):89–90.

Bollinger A, Barras JP, Mahler F. Measurement of foot artery blood pressure by micromanometry in normal subjects and in patients with arterial occlusive disease. Circulation 1976;53(3):506–12.

Marshall-Goebel K, Laurie SS, Alferova IV, et al. Assessment of Jugular Venous Blood Flow Stasis and Thrombosis During Spaceflight. JAMA Netw Open 2019;2(11):e1915011–e1915011.