Biological Barriers and Severe Mental illness: Potential Novel Interventions: Research Article

Adonis Sfera; Edelina Turturica; Dragos Turturica; Ioana Ciuperca; Daniel Ikhimiukor; Jacob J. Anton; Bernardo Boza; Garth Nicolson

doi:10.58372/2835-6276.1334

Authors

Adonis Sfera
Edelina Turturica
Dragos Turturica
Ioana Ciuperca
Daniel Ikhimiukor
Jacob J. Anton
Bernardo Boza
Garth Nicolson

DOI:

https://doi.org/10.58372/2835-6276.1334

Keywords:

gut microbes, Membrane Lipid Replacement, Oscillations, EEG gamma waves, severe mental illness

Abstract

Life is dependent on the separation of body compartments from each other and the environment. The permeability of biological barriers, including the gastrointestinal and blood-brain, depends on the integrity of cell membranes and intercellular tight junctions.

Severe mental illness is characterized by premature cellular senescence and subsequent gray matter loss in the central nervous system. Senescence-induced gut barrier disruption enables microbial migration outside the gastrointestinal tract. Systemic immune responses to gut microorganisms or their molecules may lead to neuroinflammation and the subsequent pathology.

This review discusses cellular senescence and microbial migration outside of the gastrointestinal tract along with potential strategies for restoring the gut barrier homeostasis. These approaches include membrane lipid replacement, gamma wave entrainment, red light therapy, and pulsed electromagnetic field therapy.

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