Methods of localisation of sentinel node biopsy for breast cancer patients - current and prospective overview

Review Article


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Authors

  • Monika Rezacova University Hospital Olomouc

DOI:

https://doi.org/10.58372/2835-6276.1345

Keywords:

Sentinel Node Biopsy, Breast Cancer, Prospective Overview

Abstract

Background
Breast cancer is one of the most common cancers in the adult population and due to advances in screening, its numbers are increasing every year. Assessment of sentinel node is a standardized method for staging of the axillary disease in clinically and radiologically normal axilla. Most recently attempts have been made for different than traditional dual technique.

Methods
We have looked into available research and databases to explore various available options that have been trialed or that show some prospective in sentinel node localisation. Some of these showed great potential for non-invasive/minimally invasive assessment in the future.

Results
While researching this topic, there was obvious division into operative and non-operative techniques. The operative techniques were more traditional dual technique or combination/sole tracer with newer techniques such as indocyanine green or superparamagnetic iron oxide. The non-operative techniques usually showed a combination of advanced imaging with or without biopsy.

Discussion
Although the dual technique is reliable and brings results there are some promising data from both operative and non-operative techniques. While the operative options offer mainly alternatives to the dual technique while avoiding known side effects, the non-operative techniques show quite revolutionary potential. As we are already reducing the amount of surgical intervention in the axilla, this might be an area for further research and trials.

References

Veronesi, U. ∙ Paganelli, G. ∙ Viale, G. et al., A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer, N Engl J Med. 2003; 349:546-553

Kurosumi M. Recent trends concerning sentinel lymph node biopsy for breast cancer and new methods for detection of metastasis. Breast Cancer. 2007;14(4):341. doi: 10.2325/jbcs.14.341. PMID: 17986797.

Xu L, Yang J, Du Z, Liang F, Xie Y, Long Q, Chen J, Zeng H, Lv Q. Redefining Criteria to Ensure Adequate Sentinel Lymph Node Biopsy With Dual Tracer for Breast Cancer. Front Oncol. 2020 Dec 3;10:588067. doi: 10.3389/fonc.2020.588067. PMID: 33344240; PMCID: PMC7744718.

Bove S, Fragomeni SM, Romito A, DI Giorgio D, Rinaldi P, Pagliara D, Verri D, Romito I, Paris I, Tagliaferri L, Marazzi F, Visconti G, Franceschini G, Masetti R, Garganese G. Techniques for sentinel node biopsy in breast cancer. Minerva Surg. 2021 Dec;76(6):550-563. doi: 10.23736/S2724-5691.21.09002-X. Epub 2021 Aug 2. PMID: 34338468.

Li J, Chen X, Qi M, Li Y. Sentinel lymph node biopsy mapped with methylene blue dye alone in patients with breast cancer: A systematic review and meta-analysis. PLoS One. 2018 Sep 20;13(9):e0204364. doi: 10.1371/journal.pone.0204364. PMID: 30235340; PMCID: PMC6147575.

Donker M, van Tienhoven G, Straver ME, Meijnen P, van de Velde CJ, Mansel RE, Cataliotti L, Westenberg AH, Klinkenbijl JH, Orzalesi L, Bouma WH, van der Mijle HC, Nieuwenhuijzen GA, Veltkamp SC, Slaets L, Duez NJ, de Graaf PW, van Dalen T, Marinelli A, Rijna H, Snoj M, Bundred NJ, Merkus JW, Belkacemi Y, Petignat P, Schinagl DA, Coens C, Messina CG, Bogaerts J, Rutgers EJ. Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial. Lancet Oncol. 2014 Nov;15(12):1303-10. doi: 10.1016/S1470-2045(14)70460-7. Epub 2014 Oct 15. PMID: 25439688; PMCID: PMC4291166.

Mansel RE, Fallowfield L, Kissin M, Goyal A, Newcombe RG, Dixon JM, Yiangou C, Horgan K, Bundred N, Monypenny I, England D, Sibbering M, Abdullah TI, Barr L, Chetty U, Sinnett DH, Fleissig A, Clarke D, Ell PJ. Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial. J Natl Cancer Inst. 2006 May 3;98(9):599-609. doi: 10.1093/jnci/djj158. Erratum in: J Natl Cancer Inst. 2006 Jun 21;98(12):876. PMID: 16670385.

Kurylcio A, Pelc Z, Skórzewska M, Rawicz-Pruszyński K, Mlak R, Gęca K, Sędłak K, Kurylcio P, Małecka-Massalska T, Polkowski W. Superparamagnetic Iron Oxide for Identifying Sentinel Lymph Node in Breast Cancer after Neoadjuvant Chemotherapy: Feasibility Study. J Clin Med. 2021 Jul 16;10(14):3149. doi: 10.3390/jcm10143149. PMID: 34300315; PMCID: PMC8305632.

Chapman MC, Lee AY, Hayward JH, Joe BN, Price ER. Superparamagnetic Iron Oxide Sentinel Node Tracer Injection: Effects on Breast MRI Quality. J Breast Imaging. 2020 Nov 21;2(6):577-582. doi: 10.1093/jbi/wbaa083. PMID: 38424862.

Coibion M, Olivier F, Courtois A, Maes N, Jossa V, Jerusalem G. A Randomized Prospective Non-Inferiority Trial of Sentinel Lymph Node Biopsy in Early Breast Cancer: Blue Dye Compared with Indocyanine Green Fluorescence Tracer. Cancers (Basel). 2022 Feb 10;14(4):888. doi: 10.3390/cancers14040888. PMID: 35205636; PMCID: PMC8870473.

Yadav SK, Bharath S, Sharma D, Srivastava A, Jha CK, Agarwal G, Khadka S, Singh M, Shekhar S, Goyal A. A systematic review and meta-analysis of diagnostic performance of fluorescein-guided sentinel lymph node biopsy in early breast cancer. Breast Cancer Res Treat. 2024 Jul;206(1):19-30. doi: 10.1007/s10549-024-07310-0. Epub 2024 Apr 26. PMID: 38668856.

Natsiopoulos I, Intzes S, Liappis T, Zarampoukas K, Zarampoukas T, Zacharopoulou V, Papazisis K. Axillary Lymph Node Tattooing and Targeted Axillary Dissection in Breast Cancer Patients Who Presented as cN+ Before Neoadjuvant Chemotherapy and Became cN0 After Treatment. Clin Breast Cancer. 2019 Jun;19(3):208-215. doi: 10.1016/j.clbc.2019.01.013. Epub 2019 Feb 6. PMID: 30922804.

Kamata A, Miyamae T, Koizumi M, Kohei H, Sarukawa H, Nemoto H, Hino K. Using Computed Tomography Lymphography for Mapping of Sentinel Lymph Nodes in Patients with Breast Cancer. J Clin Imaging Sci. 2021 Aug 14;11:43. doi: 10.25259/JCIS_33_2021. PMID: 34513207; PMCID: PMC8422530.

Machado P, Liu JB, Needleman L, Lazar M, Willis AI, Brill K, Nazarian S, Berger A, Forsberg F. Sentinel Lymph Node Identification in Patients With Breast Cancer Using Lymphosonography. Ultrasound Med Biol. 2023 Feb;49(2):616-625. doi: 10.1016/j.ultrasmedbio.2022.10.020. Epub 2022 Nov 26. PMID: 36446688; PMCID: PMC9943072.

Liu S, Wang H, Zhang C, Dong J, Liu S, Xu R, Tian C. In Vivo Photoacoustic Sentinel Lymph Node Imaging Using Clinically-Approved Carbon Nanoparticles. IEEE Trans Biomed Eng. 2020 Jul;67(7):2033-2042. doi: 10.1109/TBME.2019.2953743. Epub 2019 Nov 15. PMID: 31751215.

Yu Y, Tan Y, Xie C, Hu Q, Ouyang J, Chen Y, Gu Y, Li A, Lu N, He Z, Yang Y, Chen K, Ma J, Li C, Ma M, Li X, Zhang R, Zhong H, Ou Q, Zhang Y, He Y, Li G, Wu Z, Su F, Song E, Yao H. Development and Validation of a Preoperative Magnetic Resonance Imaging Radiomics-Based Signature to Predict Axillary Lymph Node Metastasis and Disease-Free Survival in Patients With Early-Stage Breast Cancer. JAMA Netw Open. 2020 Dec 1;3(12):e2028086. doi: 10.1001/jamanetworkopen.2020.28086. PMID: 33289845; PMCID: PMC7724560.

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Published

2025-10-10

How to Cite

Rezacova, M. (2025). Methods of localisation of sentinel node biopsy for breast cancer patients - current and prospective overview: Review Article. American Journal of Medical and Clinical Research & Reviews, 4(10), 1–8. https://doi.org/10.58372/2835-6276.1345

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