A Comprehensive Literature Review Examining the Efficacy of Autologous Intra-Ovarian Platelet-Rich Plasma in Women Diagnosed with POI and DOR and its Impact on ART Outcomes: Literature Review

Kavitha Krishnan Vandanath; Rizwana; A.I.Hasib Ahmed

doi:10.58372/2835-6276.1352

Authors

Kavitha Krishnan Vandanath
Rizwana
A.I.Hasib Ahmed

DOI:

https://doi.org/10.58372/2835-6276.1352

Keywords:

Autologous platelet-rich plasma, PRP, Intraovarian platelet-rich plasma, Primary Ovarian Insufficiency, POI, Diminished Ovarian Reserve, DOR, Artificial reproductive technology, ART

Abstract

Background: This extensive literature review examines the potency of autologous intra-ovarian platelet rich plasma (PRP) in women diagnosed with primary ovarian insufficiency (POR) and reduced ovarian reserve (DOR). Recent research has investigated PRP as a possible method to help improve ovarian function and improve fertility outcomes for these groups of patients.

Methods: A systematic search of medical databases was done in PubMed, Cochrane Library, Embase, and Web of Scopus done to identify relevant studies published from 2014 up to 2024. Inclusion criteria included observation studies, cohort studies and randomized controlled trials. Data extraction focused on changes in ovarian reserve parameters and ART outcomes like pregnancy rates, live birth rates and embryo quality. The studies were assessed for quality using the Newcastle-Ottawa Scale for observational studies and cohort studies and the Cochrane Risk of Bias Tools to assess the bias risk in randomized controlled trials.

Results: By using the MeSH terms related to “platelet-rich plasma,” “intra-ovarian injection” and “Diminished Ovarian Reserve", several additional relevant keywords were identified. This led to an initial search that produced 297 articles. After applying the criteria for inclusion and exclusion to evaluate these articles for eligibility,10 studies were selected for review which included a total of 1516 women. The papers included 2 randomized controlled trails, 1 retrospective study and 7 prospective studies.

Discussion: Intraovarian PRP injections show potential in enhancing ovarian function and outcomes for women with POR and POI, with some studies reporting improvements in ovarian reserve markers and pregnancy rates. However, others indicate limited benefits, highlighting variability in methodologies and PRP preparation. Future research should standardize procedures and conduct larger trials to better understand PRP's mechanisms and its impact on long-term reproductive outcomes.

Conclusion: Intra-ovarian PRP shows promise as a therapeutic option for women with POI and DOR, demonstrating improvements in ovarian reserve parameters and ART outcomes like the rates of clinical pregnancy and live births. However, further large-scale, randomized controlled trails are required to establish its extended duration of efficacy and safety. While encouraging, current evidence suggests that PRP should be considered an experimental treatment requiring additional research before widespread clinical application.

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