Erectile dysfunction in cirrhotic patients in Brazzaville

Review Article


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Authors

  • Ibobi Mauria Gilga
  • Mimiesse Monamou Jile Florient
  • Ondziel-Opara Stève Aristide
  • NGANGA Tania
  • Dimi Nyanga Yannick
  • Molami Jhonsial Joseph Bovane
  • Mikolélé Ahoui Clausina
  • Mongo-Onkouo A
  • Ngami RS
  • Motoula Latou M
  • Atipo Ibara BH
  • Ahombo Niotsebe Bénedicte
  • Odzebe Anani Séverin
  • Atipo Ibara BI

DOI:

https://doi.org/10.58372/2835-6276.1359

Keywords:

Cirrhosis, Erectile dysfunction, Brazzaville

Abstract

Objective: to determine the frequency of erectile dysfunction in cirrhotic patients in Brazzaville and to analyze the associated risk factors.

Patients and Methods: We conducted a prospective analytical study over a 7-month period, from April 1 to October 30, 2024, in three hospital centers specialized in the management of cirrhotic patients. All consenting cirrhotic patients aged 18 years and older were included. The variables studied were sociodemographic parameters, clinical and biological characteristics, and erectile dysfunction.

Results: A total of 80 patients were included. The mean age was 49.60 ± 14.45 years, ranging from 24 to 79 years. Among them, 88.75% had decompensated cirrhosis. Erectile dysfunction was found in 85% of patients. Age over 55 years (p < 0.0104), a WHO score ≥ 2 (p < 0.047), and Child-Pugh class C (p < 0.006) were associated with erectile dysfunction.

Conclusion: Erectile dysfunction is common among cirrhotic patients in Brazzaville, highlighting the need for systematic screening for erectile dysfunction in this population.

References

Benhamou, JP and Erlinger, S. (2000) Liver and biliary tract disease. Flammarion, Paris, 223 p.

Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380:2095–128.

Blachier M, Leleu H, Peck-Radosavljevic M, Valla DC, Roudot-Thoraval F. The burden of liver disease in Europe: a review of available epidemiological data. J Hepatol 2013; 58: 593–608.

Hoyert DL, Xu J. Deaths: preliminary data for 2011. Natl Vital Stat Rep 2012; 61: 1–52.

Ganne-Carrié N. Epidemiology of liver cirrhosis. Rev Prat. 2017 Sep; 67(7 ): 726-730. French. PMID: 30512765.

Cales P. Can cirrhosis be diagnosed early? Le concours médical. 1995: 117-37.

Saunders JB, Walter JR, Davis P, Paton A. A 20-year prospective stage of cirrhosis. BMJ 1981; 282: 263-266.

Mimiesse, JF, Marlyse, NM, Clausina, AA, Arnaud, MO, Lucie, A.-IO, Bossali, F., Itoua-Ngaporo, AN, Ngami, RS, Honal, MG, Gassaye, D., Irénée, AIB and Jean-Rosaire, I. (2020) Evolutionary and Prognostic Aspects of Cirrhosis at the University Hospital of Brazzaville (Congo). Open Journal of Gastroenterology, 10, 23-29. https://doi.org/10.4236/ojgas.2020.101003

Maimone S, et al. Erectile dysfunction in compensated liver cirrhosis. Dig Liver Say (2018). https://doi.org/10.1016/j.dld.2018.10.015

Booth FW, Roberts CK, Laye MJ. Lack of exercise is a major cause of chronic diseases. Compr Physiol 2012;2: 1143–211.

Danoff A, Khan O, Wan DW, et al. Sexual dysfunction is highly prevalent among men with chronic hepatitis C virus infection and negatively impacts health-related quality of life. Am J Gastroenterol. 2006;101:1235–1243 .

Neong SF, Billington EO, Congly SE. Sexual dysfunction and sex hormone abnormalities in patients with cirrhosis: review of pathogenesis and management. Hepatology. 2019;69:2683–2695 .

Kaymakoglu S, Okten A, Cakaloglu Y, et al. hypogonadism if not related to the etiology of liver cirrhosis. J Gastroenterol. 1995;30: 745–750.

Sinclair M, Grossmann M, Gow PJ, et al. testosterone in male with advanced liver disease: abnormalities and implications. J Gastroenterol Hepatol. 2015;30: 244–251.

Laurent MP, Hammond GI, Blokland M, et al. sex hormone binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis. SciRep. 2016;6: 353–359.

Gordon GG, Olivo J, Rafil F, et al. Conversion of androgens to estrogens in cirrhosis of the liver. J Clin Endocrinol Metab . 1975;40:1018–1026 .

Haridy MA, Mohamed MF, Badr AF, Mekky MA, Abdelmola OM, Mohammedin EA, et al. Erectile dysfunction in patients with liver cirrhosis; upper Egypt experience [Internet]. 2023 [cited 26 Apr 2024]. Available from: https://www.researchsquare.com/article/rs-2464624/v1

Le Bras, M., Tricolat, R., Clerc, M., Loubiere, R., Beda and Bertrant, E. (1978) Etiological Factors of Primary Liver Cancer in Cote d'Ivoire. Gastroenterologie Clinique et Biologique, 2, 679-688.

Ibara, JR, Ossendza, RA and Okouo, M. (1999) Primary Liver Cancers in Congo: Hospital Study of 558 Cases. Black African Medicine, 46, 394-397.

Mpaka, SM, Natuhoyila , AN, Tshikwela , ML, Nsukini, SM, Nlombi , CM, Fuele , SM, Yaba, ATW, Tchokonte -Nana, V., Okwe , AN, Djuikoue , IC, Mokondjimobe , E. and Longo-Mbenza, B. (2021) Liver Cirrhosis Investigation Using Abdominal Ultrasound as Gold Standard Test and Some Bioclinical Markers with Different Levels of Diagnostic Accuracy in Chronic Liver Disease Patients between 1990 and 2004 at Teaching Hospital of Kinshasa, Democratic Republic of the Congo. Open Access Library Journal , 8 , 1-15. doi: 10.4236/oalib.1108070 .

S. Driouiche; A. Mernissi; M. Lahlali; A. Lamine; H. Abid; A. Elmekkoui ; M. Elyoussfi; D. Benajah; M. Elabkari; A. Ibrahimi; N. Lahmidani. Epidemiological and evolutionary profile of hepatic cirrhosis. Moroccan Journal of Medical Sciences. 2019 ; Volume 23; No. 1.

Yao Bathaix , MF, Bagny , A., Mahassadi , KA, et al. (2015) Prognostic Factors for Cirrhosis Hospital in Abidjan (Ivory Coast). Journal of Gastroenterology, 5, 103-109. https://doi.org/10.4236/ojgas.2015.57017

Sehonou, J., Kodjoh, N., Sake, KL, et al. (2010) Liver cirrhosis in Cotonou (Republic of Benin): Clinical aspects and factors related to death. Tropical Medicine, 70, 375-378.

Mbendi NC, Nkodila A, Zingondo JC B, Manangama CN, Taty PL, Ngoma JA. Epidemiological, clinical and evolutionary aspects of liver cirrhosis in Kinshasa: A multicenter study. African Annals of Medicine, Vol. 11 No. 2 (2018).

Jagdish et al. Erectile dysfunction in cirrhosis: Its Prevalence and Risk Factors, Journal of Clinical and Experimental Hepatology, http://doi.org/10.1016/j.jceh.2022.05.001

Mustapha Ahmed Harydi, Mohamed Fakhry Mohamed, Ahmed Fathy Bdr et al. Erectile dysfunction in patients with liver cirrhosis: experience from Upper Egypt. Research Square. https://orcid.org/0000-0002-9372-185

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Published

2026-01-05

How to Cite

Ibobi Mauria Gilga, Mimiesse Monamou Jile Florient, Ondziel-Opara Stève Aristide, NGANGA Tania, Dimi Nyanga Yannick, Molami Jhonsial Joseph Bovane, Mikolélé Ahoui Clausina, Mongo-Onkouo A, Ngami RS, Motoula Latou M, Atipo Ibara BH, Ahombo Niotsebe Bénedicte, Odzebe Anani Séverin, & Atipo Ibara BI. (2026). Erectile dysfunction in cirrhotic patients in Brazzaville: Review Article. American Journal of Medical and Clinical Research & Reviews, 5(1), 1–8. https://doi.org/10.58372/2835-6276.1359

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