Clinical management and therapy of secondary postpartum hemorrhage

Research Article


Abstract views: 18 / PDF downloads: 21

Authors

  • Felis S

DOI:

https://doi.org/10.58372/2835-6276.1121

Keywords:

Severe morbidity, hemorrhage, maternal outcomes, maternal safety, obstetric readmissions

Abstract

Secondary postpartum hemorrhage, defined as excessive bleeding that occurs more than 24 hours after delivery and up to 12 weeks postpartum, occurs in approximately 1% of pregnancies. In the event of secondary hemorrhage, several specific etiologies should be considered. Uterine atony (perhaps secondary to retained products of conception) with or without infection contributes to secondary hemorrhage. Ultrasound evaluation can help identify intrauterine tissue. Endometritis should be strongly suspected in the presence of uterine tenderness and a low-grade fever. Secondary postpartum hemorrhage also may be the first indication of bleeding disorders such as von Willebrand disease. Treatment should be focused on the etiology of the hemorrhage and may include uterotonic agents and antibiotics, but if these fail to resolve the problem or if retained products of conception are suspected, uterine curettage may be necessary. If treating endometritis, broad antibiotic coverage with clindamycin and gentamicin is a common choice, although other combinations also are used. Often the volume of tissue removed by curettage is relatively small yet bleeding usually subsides promptly. Concurrent ultrasound assessment at the time of curettage can help prevent uterine perforation. Patients should be counseled about the possibility of hysterectomy before initiating any operative procedure

References

Cunningham FG, Leveno KJ, Bloom SL, et al. Williams Obstetrics, 24th ed. McGraw-Hill, 2014 The puerperium pp 670, Obstetrical Haemorrhage pp 783

King PA, Duthie SJ, Dong ZG, Ma HK. Secondary postpartum hemorrhage. Aust N Z J Obstet Gynaecol 1989;29: 394–8

Floyd L. (1999) Survey of women’s experiences of vaginal loss after childbirth. Practising Midwife, 2, 43

Neill A, Thornton S. Secondary postpartum hemorrhage. J Obstet Gynaecol 2002; 22:119–22

Alexander J, Thomas PW, Sanghera J. Treatments for secondary postpartum hemorrhage. Cochrane Database Syst Rev 200

Legro R.S., Price F.V., Hill L.M. and Caritis S.N. (1994) Nonsurgical management of placenta percreta: a case report. Obstetrics and Gynecology, 83, 847–849.

Weissbach T, Haikin-Herzberger E, Bacci-Hugger K et al. Immediate postpartum ultrasound evaluation for suspected retained placental tissue in patients undergoing manual removal of placenta. Eur J Obstet Gynecol Reprod Biol. 2015;192: 37-40. doi:10.1016/j. ejogrb.2015.06.004

Guarino A, Di Benedetto L, Assorgi C et al. Conservative and timely treatment in retained products of conception: a case report of placenta accreta retention. Int J Clin Exp Pathol. 2015; 8:13625-9.

Rose G.L. and Chapman M.G. (1986) Aetiological factors in placenta praevia—a case control study. British Journal of Obstetrics and Gynaecology, 93, 586–588.

Clark S.L., Koonings P.P. and Phelan J.P. (1985) Placenta praevia/accreta and prior cesarean section. Obstetrics and Gynecology, 66, 89–92.

Hung T.H., Shau W.Y., Hsieh C.C., Chiu T.H., Hsu J.J. and Hsieh T.T. (1999) Risk factors for placenta accreta. Obstetrics and Gynecology, 93, 545–550

Bardou P, Orabona M, Vincelot A, Maubon A, Nathan N. Uterine artery false aneurysm after caesarean delivery: an uncommon cause of post-partum hemorrhage. Ann Fr Anesth Reanim 2010; 29:909–12

Bhatt A, Odujebe O, Bhatt S, Houry D. Uterine artery pseudoaneurysm rupture: a life-threatening presentation of vaginal bleeding. Ann Emerg Med 2010; 55:460–3

Paraskevaides E, Stuart B, Gardeil F. Secondary postpartum hemorrhage from non-dehisced lower caesarean section scar: a case for hysteroscopy. Aust N Z J Obstet Gynaecol 1993;33: 427

Tidy JA, Rustin GJ, Newlands ES, et al. Presentation and management of choriocarcinoma after non molar pregnancy. Br J Obstet Gynaecol 1995; 102:715–9

Economides DL, Kadir RA, Lee CA. Inherited bleeding disorders in obstetrics and gynecology. Br J Obstet Gynaecol 1999; 106:5–13

Nichols WL Jr, Hultin MB, James AH, et al. The Diagnosis, Evaluation, and Management of von Willebrand Disease. Bethesda, MD: National Heart, Lung, and Blood Institute, National Institutes of Health; 2007.

Kadir RA, Economides DL, Braithwaite J, Goldman E, Lee CA. The obstetric experience of carriers of hemophilia. Br J Obstet Gynaecol 1997; 104:803–10

Achiron R, Goldenberg M, Lipitz S, Mashiach S. Transvaginal duplex Doppler ultrasonography in bleeding patients suspected of having residual trophoblastic tissue. Obstet Gynecol 1993; 81:507–11

Zuckerman J, Levine D, McNicholas MM, et al. Imaging of pelvic postpartum complications. Am J Roentgenol 1997; 168:663–8

Neill AC, Nixon RM, Thornton S. A comparison of clinical assessment with ultrasound in the management of secondary postpartum hemorrhage. Eur J Obstet Gynecol Reprod Biol 2002; 104:113–5

Bonnar J., Guillebaud J., Kasonde J.M. and Sheppard B.L. (1980) Clinical applications of fibrinolytic inhibition in gynecology. Journal of Clinical Pathology, 14, 55–59

Alok K, Hagen P, Webb JB. Tranexamic acid in the management of postpartum hemorrhage. BJOG 1996; 103:1250–1

Ducloy-Bouthors AS, Jude B, Duhamel A, et al. High-dose tranexamic acid reduces blood loss in postpartum hemorrhage. Crit Care 2011; 15: R117

Ferrer P, Roberts I, Sydenham E, Blackhall K, Shakur H. Anti-fibrinolytic agents in post-partum hemorrhage: a systematic review. BMC Pregnancy Childbirth 2009; 9:29

Novikova N, Hofmeyr GJ. Tranexamic acid for preventing postpartum hemorrhage. Cochrane Database Syst Rev 2010.

Boehlen F, Morales MA, Fontana P, Ricou B, Irion O, de Moerloose P. Prolonged treatment of massive postpartum hemorrhage with recombinant factor VIIa: case report and review of the literature. BJOG 2004; 111:284–7

Lurie S, Appleman Z, Katz Z. Subendometrial vasopressin to control intractable placental bleeding. Lancet 1997; 349:698

Guillebaud J. (1994) Contraception: your questions answered, pp. 420–421. Edinburgh, Churchill Livingstone.

JohansonR, Kumar M, ObhraiM, Young. Management of massive postpartum hemorrhage: use of a hydrostatic balloon catheter to avoid laparotomy. BJOG 2001; 108:420–2

Lynch C, Coker A, Lawal AH, Abu J, Cowen MJ. The B-Lynch surgical technique for the control of massive postpartum hemorrhage: an alternative to hysterectomy? Five cases reported. Br J Obstet Gynaecol 1997; 104:372–5

Pelage JP, Soyer P, Repiquet D, et al. Secondary postpartum hemorrhage: treatment with selective arterial embolization. Radiology 1999; 212:385–9

Linee Guida dell’Istituto Superiore di Sanità. Emorragie post partum: come prevenirla e come curarla. Data Pubblicazione Ottobre 2016

Bagshawe KD, Dent J, Newlands ES, Begent RHJ, Rustin GJS. The role of low-dose methotrexate and folinic acid in gestational trophoblastic tumors (GTT). BJOG 1989;96: 795–802

Downloads

Published

2023-12-27

How to Cite

Felis S. (2023). Clinical management and therapy of secondary postpartum hemorrhage: Research Article. American Journal of Medical and Clinical Research & Reviews, 2(12), 1–9. https://doi.org/10.58372/2835-6276.1121

Issue

Section

Articles