THE ANALYSIS AND EPIDEMIOLOGICAL A VACCINATION OF ROTAVIRUS 2021 IN TIMOR-L ESTE.: Research Article

Carlos Boavida Tilman

doi:10.58372/2835-6276.1033

Authors

Carlos Boavida Tilman

DOI:

https://doi.org/10.58372/2835-6276.1033

Keywords:

Analysis, Epidemiological, Vaccination, Rotavirus, Antigens, Gastroenteritis

Abstract

Introduction: Rotavirus (RV) are the main viral agents causing acute gastroenteritis (GE) in children, being aware of thousands of deaths in children with diarrhea, globally, especially in developing countries, the case of Timor-Leste. Recent studies have shown the present of rotavirus antigens in serum (antigens) and feces of animals and humans, and this finding may be related to extraintestinal therapists and greater seriousness of the disease. This study was carried out in pediatric room hospitals in Dili, Baucau, Maubessi, Malian a and private clinics of non-profit mission in partnership with the Government.

Objectives: To know how to detect antigenic cases caused by rotavirus (RV) among children hospitalized with acute gastroenteritis (GE) in pediatric room hospitals in Timor-Leste.

Methodology: In the collection of certain and 560 children information, 4 46 paired samples of feces and serum were collected for analysis using the enzymatic immune method (ELISA). Initially, the coverage was sufficient in the sample collection with the support of the employees of the vaccination program manager services in state and private clinics with support of cooperation and professional trust.

Discussion result: Rotavirus stool research was positive in 23% (104/446) of the samples, and antigens were found in 3 4.5% (38/104) of these patients. The severity of the disease was analyzed using the universal rascal and vesicaria score, and no statistically significant difference was observed between patients with and without antigens (p= 0.110); however, a higher number of episodes and duration of vomiting were observed in patients with antigens (p=0.012 and p=0.002, respectively). Antigens is common in children hospitalized with acute gastroenteritis caused by rotavirus in Timor-Leste and is associated with a greater number of episodes and duration of vomiting. It is observed the coordination of data collection and epidemiological surveillance control between the investigator and hospitals is considered 69.7% good in the practice of implementation of the study. The rotavirus vaccination coverage rate is higher than 75% and 38% lower for pentavalent the 3 doses of vaccination that registers and officially documented.

Conclusion: However, a more comprehensive epidemiological analysis involving molecular tests is necessary to complement the results achieved with regard to genotypes involved in future research.

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